JWST observations reveal snapshot insights into exoplanet atmospheres confirming often for the first time the presence of chemically rich environments. For most exoplanets, cloud particles form that affect their atmospheric environments by multiple feedback processes.  The physical understanding of such observations  therefore requires comprehensive modelling approaches that combine 3D radiation-hydrodynamic simulations with appropriately complex gas phase and cloud formation models. I will therefore  present: 1) Our recent advances in detailed, kinetic cloud formation modelling where we utilise quantum-chemical simulations and laboratory experiments to support our model building, and 2) how we utilise 3D global simulations to define atmospheric regimes that help to characterise exoplanets in different planetary system configurations. Lastly, I plan on discussing the potential of polarimetry as well as future space missions like PLATO to strengthen the impact of the JWST observational efforts. Those unable to attend the colloquium in person are invited to participate online through Zoom (Meeting ID: 942 0262 2849, passcode 792771) using the link: https://eu02web.zoom-x.de/j/94202622849?pwd=dGlPQXBiUytzY1M2UE5oUDRhbzNOZz09 Professor Helling is available for meetings by arrangement with her host, Hans Ludwig (H.Ludwig@lsw.uni-heidelberg.de).