In this talk I will discuss about possible direct and indirect signatures of additional Yukawa couplings that might exist in nature. The context is general Two Higgs Doublet Model. Such additional Yukawa couplings can account for the observed baryon asymmetry of the Universe and, can have exquisite signatures at the LHC, Belle-II experiments or at the future electron-positron Linear Collider. A discovery may help us understand the mechanism behind the matter-antimatter asymmetry of the Universe.