Today:
Upcoming:
Optical Geometry and the Magnetoelectric Effect
Marcus Werner
Wed, 25 Sep 2019, 11:00
TBD
Abbas Askar (Lund)
Thu, 26 Sep 2019, 11:00
TBD
Paola Pinilla
Fri, 27 Sep 2019, 15:00
TBD
Ross Church (Lund Observatory)
Thu, 10 Oct 2019, 11:00

How Cell Collectives make Decisions

Prof. Dr. Joachim Spatz , MPI for Medical Research, Dept. Cellular Biophysics & University of Heidelberg, Dept. Biophysical Chemistry
Regulating the emergence of leading individuals is a central problem to collectively migrating biological entities. For example, leaders in the mobile animal groups arise through collective decision making of the followers. However, the fundamental control of leader selection remains unclear in the physiologically relevant collective migration of epithelial cells. Here we present that the selective emergence of leader cells at the epithelial wound-margin depends on the dynamics of the follower cells and is spatially limited by the length-scale of collective force transduction. Owing to the dynamic heterogeneity of the monolayer, cells behind the prospective leaders manifest locally increased traction and monolayer stresses much before these leaders display any phenotypic traits. Once formed, the territory of a leader can extend only to the length up-to which cells can pull on their neighbors. These findings provide a novel mechanobiological-insight into the hierarchy in cell collectives during epithelial wound healing.
Physikalisches Kolloquium
24 May 2019, 17:00
KIP, INF 227, Otto-Haxel-Hörsaal

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